Carolina L Haass-Koffler
Providence, RI 02912
Biography
Dr. Carolina Haass-Koffler is a translational Investigator who coalesces preclinical and clinical research towards examining biobehavioral mechanisms of addiction and developing novel medications. Her education includes chemistry from the University of California, Berkeley, pharmacology from the University of California, San Francisco, neuroscience from the Gallo Center and human laboratory studies from Brown University. During her academic career, she has developed an interdisciplinary skill-set that is helping her to conceptualize and execute bench-to-bedside research and to facilitate the cross-talk between academia, NIH and the pharmaceutical industry. She developed a novel stress-induced alcohol drinking paradigm from her neuroscience work which is currently tested in a medication human laboratory study. She is also studying the role of neuroendocrine pathways in alcoholism (e.g.: ghrelin, leptin, insulin) to identify new treatment targets and completing a series of translational experiments on the role of the corticotropin releasing factor binding protein in alcohol use disorder.
Publications
Haass-Koffler CL, Long VM, Farokhnia M, Magill M, Kenna GA, Swift RM, Leggio L Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study.. Neuropharmacology. 2019; 158 : 107711.
Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, Di Guglielmo G, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP Probenecid Reduces Alcohol Drinking in Rats: is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder? . Alcohol and Alcoholism. 2019;
Haass-Koffler, Carolina L, Goodyear, Kimberly, Loche, Antonella, Long, Victoria M, Lobina, Carla, Tran, Harrison H, Cacciaglia, Roberto, Swift, Robert M, Colombo, Giancarlo, Leggio, Lorenzo Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: A translational study in rats and humans.. Journal of Psychopharmacology/Journal of Psychopharmacology. 2018; 32 (2) : 163-173.
Haass-Koffler, Carolina L, Goodyear, Kimberly, Zywiak, William H, Leggio, Lorenzo, Kenna, George A, Swift, Robert M Comparing and Combining Topiramate and Aripiprazole on Alcohol-Related Outcomes in a Human Laboratory Study.. Alcohol and Alcoholism/Alcohol and Alcoholism. 2018; 53 (3) : 268-276.
Awards
2019
- American College of Neuropsychopharmacology (ACNP) Travel Award, Orlando FL
- Travel Fellowship Winter Conference on Brain Research
2018
- NIAAA R13 International Travel Award, International Society Biomedical Research Alcoholism (ISBRA), Kyoto, Japan
- Dean's Award for Excellence in Research Collaboration, School Public Health, Brown University